Carter, Great question! Chemically, the artificial sweeteners are different from sugar. They can fool our taste buds, but not the flower. Flowers need sugars that are simple chemically. The flower can (in some instances) modify the sugar compound a bit to be able to use it. Not so for artificial sweeteners. They are too different chemically from sugars flowers need. Although I haven’t tried this myself, my hypothesis is that artificial sweeteners would work about as well (which is not good) as aspirin and other home remedies. Unless the artificial sweeteners had some simple sugars in them, I would suspect most work similarly. However, if one of those compounds was toxic to the flower, it should shorten the longevity of the flower.   - Bridget